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FILAMENTOUS FUNGAL PLATFORMS FOR PROTEIN INNOVATION

C1 and Dapibus™ – part of a growing ecosystem of recombinant platforms redefining scalability

life sciences

Scalable Platforms for Recombinant, Animal-Free Protein Solutions

Engineered for speed, scale, and sustainability — Dyadic’s microbial expression systems redefine what’s possible in recombinant protein manufacturing. From C1 and Dapibus™ to future platforms, each is built for industrial performance and animal-free production.

C1
Production-Proven Platform

· Proven at commercial scale for complex proteins
· Phase I clinical validation
· High yield, low cost
· GMP capable and scalable

Dapibus™
Yield and Cost Optimized

· High-yield, animal-free protein production
· Suited for food, nutrition, and industrial use
· Sustainable, low-cost manufacturing
· Low-carbon precision fermentation

Emerging Platforms
Next-Generation Microbial Systems

· Expanding strain diversity and host option
· Enabling new functionalities across microbes
· Adaptable expression for multiple industries
· Built for future-ready innovation

Key Attributes of Dyadic Fungal expression systems:

Proven at Scale

>100,000 L fermentations

RUO & GMP Compatible

Efficient tech transfer

Low-Cost Production

High-yield; Inexpensive media

Versatile Expression System

Complex and standard products

Robust Genetic Toolbox

Precision genetic engineering for higher productivity

From Gene to Scalable Protein

Dyadic’s filamentous fungal platforms harness the natural efficiency of fungi to transform genetic concepts into high-yield, animal-free proteins at industrial scale. These systems thrive on low-cost media, enabling economical production without compromising performance.

The C1 and Dapibus™ expression systems combine robust fungal strain engineering with flexible process design to deliver exceptional productivity across diverse applications. Operating efficiently over a wide range of temperatures (20–45°C) and pH (5–8), both platforms maintain stability and yield under varying fermentation conditions.

Because our fungal hosts secrete proteins directly into the culture, recovery is simplified — allowing downstream purification to be tailored for each product’s purity, functionality, and partner requirements.

Life Science

From Design to Scale

A Powerful Genetic Toolbox

CRISPR licensing for efficient strain optimization------------------------------------------------

Strong promoter and signal libraries for tunable, high-efficiency expression

Folding and secretion factors to ensure proper folding and stability

Combinatorial engineering for rapid, data-driven optimization

Flexible integration systems for stable, high-producing strains

Glycoengineering tools for humanized or custom glycan profiles

Process adaptability for seamless scale-up from gene to production

Why It Matters

• Lower COGS - high-yield, efficient fungal expression
• 100% animal-free production -
ethical, regulatory, and market advantages
• Sustainable -
low-carbon fermentation using inexpensive media
• Proven scalability -
lab to >100,000 L for reliable commercial output
• Flexible process design -
for diverse proteins and applications
• Consistent quality and performance -
across temperature and pH ranges