Scientific Collaborations

Major Scientific Collaborations

PARTNER OVERVIEW
SCRIPPS, Jupiter, Florida
Jupiter, Florida
  • One of the world’s largest and most reputable biomedical research organizations
  • Dr. Richard Lerner, former President of Scripps, is the Chairman of Dyadic’s Scientific Advisory Board
  • Performed the first automatic annotation of the C1 genome, allowing identification of key metabolic functions that influence expression of genes and facilitate the use of advanced genetic technologies
  • Re-annotated the C1 genome in 2009-2010
    • Expands knowledge of C1 genetics
    • Provides information and knowledge to improve C1 platform technology — do more for less at higher yields
    • Provides new product candidates and enzyme catalysts to improve manufacturing processes
    • Enables entry into new markets
BTR logo

Manitowoc, Wisconsin

  • Bio-Technical Resources (BTR), a division of Arkion Life Sciences, is a contract research organization with expertise in areas of strain and process development for fermentation of microbial products
  • Dyadic has worked with BTR continuously since 1995 on a variety of development programs
    • Production of several commercial enzyme products, most notably C1
    • Commercial scale production of neutral cellulase enzymes
    • Development and commercialization of recombinant cellulase and xylanase enzyme products utilizing the Dyadic platform technology
Zeist, The Netherlands

Zeist, The Netherlands

  • TNO Quality of Life is a contract research organization sponsored by the Dutch government and is one of the institutes comprising The Netherlands Organization for Applied Scientific Research
  • The TNO scientists working with Dyadic are widely recognized as leaders in the area of fungal genetics and molecular biology
  • Since 1998, Dyadic has worked with TNO on a variety of development programs
    • Development of technologies for gene expression, gene knock outs and gene discovery (low protease C1 strains and C1 molecular toolkit)
    • Optimization of the C1 platform technology
Moscow University Logo

Moscow State University

  • Dyadic’s longest research collaboration
  • Dyadic works with experts in industrial enzymology at the Division of Chemical Enzymology in the Chemical Department, as well as collaborating with microbiology experts at the Russian Academy of Sciences
  • In 1992, Dyadic initiated the development of its first enzyme product, an acid cellulase produced from Trichoderma, which was commercialized in 1994
  •  Isolated the C1 wild type strain and have spent over 20 years purifying, characterizing and applying enzymes produced from C1 and numerous other fungi for multiple applications
  • Moscow State has been instrumental in the discovery of new enzyme products for Dyadic and in detailed characterization and analysis of existing enzyme products
  • The R&D efforts conducted in collaboration with Moscow State over the last two decades serve as a significant foundation for Dyadic’s lignocellulosic-related research

Other Scientific Collaborations

PARTNER OVERVIEW
Beckman Coulter Genomics
  • Collaborated with Agencourt Biosciences Corporation (now Beckman Coulter Genomics) to sequence the C1 genome in 2005, which led to discovery and patenting of novel genes as well as scientific knowledge that improved the C1 platform technology
Bio-Mimetic project
  • Research consortium funded by the European FP7 program, commencing in July 2012
  • Converting lignin into high value sustainable commercial products such as adhesives, detergents, and cosmetics
Clariant
  • Entered into a C1 Optimization Agreement in 1995
Concordia University
  • 2009 collaboration on the development of Dyadic’s Aspergillus fungal strain
DISCO
  • Research consortium funded by the European FP7 program
  • Substantial contributions to Dyadic’s library of C1 enzymes (cellulases and hemicellulases)
Fibre-XM Program
  • Project with EUREKA program to develop a process (enzymes and chemical conversions) to modify cellulose fibers to obtain new properties in order to open up new avenues for the use of plant fibers, microbial cellulose and solid cellulose
Keygene
  • Resequenced the C1 genome in 2009
Kluyver Center
  • Partnership that employs microbial genomics to improve microorganisms for use in industrial fermentation processes
National Institute for Bioprocessing Research and Training (NIBRT)
  • Partnership with the National Institute for Bioprocessing Research and Training (NIBRT)
  • 2006 partnership characterized the glycosylation pattern of select C1 proteins
NEMO
  • Research consortium funded by the European FP7 program
  • Developing enzymes and microorganisms for the conversion of lignocelluloses into bioethanol
Royal Nedalco (now part of Cargill)
  • Development of optimal enzyme preparations for the release of sugars from various feedstocks
Savannah River National Laboratory (SRNL)
  • Development of a cellulosic process for ethanol production
University of Florida
  • Partnership in 2006 analyzed the effects of fibrolytic enzymes on the performance of dairy cattle
Wageningen University
  • Dyadic Netherlands is located in Wageningen and has strong ties with the Wageningen University and Research Centre (WUR)

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